Paget Disease Definition in Medical
Paget disease definition is a rare type of breast cancer, characterized by abnormal growth of cancer cells around the nipple. Cancer usually starts from the small ducts of the nipple before it spreads to the surface of the nipple and surrounding skin (areola).
Most people with this condition also have breast cancer in the same breast. Breast cancer may be an invasive type or a pre-invasive cancer, often referred to as ductal carcinoma in situ, or DCIS.
Treatment usually includes removal of affected parts, including the nipple and areola, and followed by chemotherapy or radiation therapy. Breast reconstructive surgery is sometimes done because the removal of the nipple and the areola causes damage to the shape of the breast, which is cosmetically unpleasant for some people.
How often is Paget Disease?
Statistics show, about 2 of 100 cases of breast cancer found as Paget disease in the nipple. It is not known exactly how many people are diagnosed with this condition in which the person does not have invasive breast cancer or DCIS underlying the condition of Paget’s disease on her nipples.
Symptoms of Paget Disease
The main symptoms are changes in the nipple and surrounding skin (areola), accompanied by the following symptoms:
- The area of the nipple turns to hard, palpable as a lump and scaly – it looks like her skin is experiencing symptoms of dermatitis or eczema
- The nipple area of the breast looks reddish and sometimes looks very red
- There may be cuts on the skin around the nipple
- Nipples look evenly or drawn inward
- There is fluid or blood coming out of the nipple
- Itching or pain in the nipple area of the breast
- There may be lumps in other parts of the same breast
Treatment of Paget Disease
Everyone has different circumstances with each other, so the therapy of Paget’s disease on the nipples experienced from one person to another may vary based on the individual’s individual circumstances.
Paget’s disease therapy on the nipple will depend on how extensively this condition occurs in the nipple, areola and breast.
When Paget’s disease of the nipple is found to be the only condition that occurs in the breast, therapy usually includes:
- Breast surgery
If invasive breast cancer or DCIS is found in the same breast then the recommended therapy may be different.
In addition, some people with Paget’s disease of the nipple, decide to undergo different treatments in addition to medical treatment, or become available clinical trial participants.
Surgery in Paget’s disease of the nipple involves removal of the nipple and tissue around the nipple. If the nipple is the only area affected, then it may be just a little nipple and a healthy area around the raised nipple. This method of surgery is known as surgical removal of some breast (breast conserving surgery, BCT).
The removal of the entire breast (mastectomy) and / or removal of one or more lymph nodes in the armpits may be required in some patients.
In those with Paget’s disease on the nipple, radiotherapy is almost always advocated after partial breast removal surgery (breast conserving surgery, BCT) is completed. Radiotherapy is also sometimes recommended when surgery is performed surgical removal of the entire breast (mastectomy).
For those with Paget’s disease on the nipple, radiotherapy may be the only necessary treatment after a biopsy (done in order to diagnose) is done.