Causes of Acromegaly and Risk Factors
The cause of acromegaly is the high production of growth hormone (GH) produced by the pituitary gland. Ninety-five percent of acromegaly cases show a tumor in the pituitary gland, which is a cause of increased GH production. In rare cases, heredity can be a triggering factor.
The pituitary gland is located at the bottom of the brain and serves to produce various important hormones for the body, one of which is growth hormone (GH). GH triggers the liver in producing insulin-like growth factor I (IGF-I) as a stimulant of bone growth and tissue. Excess GH levels will affect the production of IGF-I, triggering abnormal growth in body tissues, muscles, and bones.
For patients with pituitary tumors, acromegaly may be accompanied by other symptoms, ie when the tumor presses on the nerve and tissue around the pituitary, or if the tumor also causes excessive production of thyroid hormones.